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Scleredema

Editor: unassigned

Clinical Features:

  • Most commonly associated with diabetes mellitus, less often with monoclonal gammopathy or following an acute respiratory infection
  • Presents as thickening and induration of the upper trunk, with nonpitting indurating edema in advanced cases.

Histologic Features:

  • Markedly thickened dermis with increased collagen that may replace subcutaneous fat
  • Thick, hyalinized collagen bundles separated by clefts
  • Increased dermal mucin interspsersed between collagen bundles may be seen on special stains.
  • No increase in dermal fibroblasts

 

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Cases associated with this book:

  • 42 year-old man with tightening of neck and upper back
    Author: April W. Armstrong M.D.
    Diagnosis: Scleredema Diabeticorum
    clinical
    image

  • 54 year-old HIV-positive male with upper back thickenning.
    Author: Artur Zembowicz M.D. Ph.D.
    Diagnosis: Scleredema
    Conference: Dr. Z's Consultations
  • Scleredema
    Author: Stephen Lyle, M.D., Ph.D.
    Diagnosis: Scleredema
    Scleredema 1Scleredema 2Scleredema 3Scleredema 4

    Conference: DermatopathologyConsultations.com Teaching Collection