Scleredema

    Clinical Features:

    • Most commonly associated with diabetes mellitus, less often with monoclonal gammopathy or following an acute respiratory infection
    • Presents as thickening and induration of the upper trunk, with nonpitting indurating edema in advanced cases.

    Histologic Features:

    • Markedly thickened dermis with increased collagen that may replace subcutaneous fat
    • Thick, hyalinized collagen bundles separated by clefts
    • Increased dermal mucin interspsersed between collagen bundles may be seen on special stains.
    • No increase in dermal fibroblasts

     

    External Links:

     

    Cases associated with this book:

  • Scleredema
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection
  • 54 year-old HIV-positive male with upper back thickenning.
    Author: Artur Zembowicz M.D. Ph.D.
    Conference: Dr. Z's Consultations
  • 42 year-old man with tightening of neck and upper back
    Author: April W. Armstrong M.D.