Solitary circumscribed neuroma (palisaded encapsulated neuroma)

    Article Contributors: 
    Sean Klepper M.D.
    Stephen Lyle, M.D., ...

    Clinical Features:

    • Most common on the face of middle-aged and older adults
    • Presents as as a solitary skin-colored papule

    Histologic Features:

    • Well circumscribed intradermal nodule; rarely multinodular
    • Partially encapsulated
    • Composed of fascicles of spindle cells separated by artefactual clefts
    • The cells have wavy, hyperchromatic nuclei and relatively abundant pale eosinophilic cytoplasm.
    • Palisading is not typically a prominent feature, despite the alternative name of the tumor.
    • The tumor may show attachment to a normal nerve.
    • There is occasionally prominent vascularity.
    • The tumor cells are positive for S-100 and numerous axons are present which stain for neurofilament protein.  The capsule is positive for EMA, in keeping with a perineurial origin.

    Cases associated with this book:

  • Solitary circumscribed neuroma
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: Teaching Collection