Clinical Features:

• Most common on the face of middle-aged and older adults
• Presents as as a solitary skin-colored papule

Histologic Features:

• Well circumscribed intradermal nodule; rarely multinodular
• Partially encapsulated
• Composed of fascicles of spindle cells separated by artefactual clefts
• The cells have wavy, hyperchromatic nuclei and relatively abundant pale eosinophilic cytoplasm.
• Palisading is not typically a prominent feature, despite the alternative name of the tumor.
• The tumor may show attachment to a normal nerve.
• There is occasionally prominent vascularity.
• The tumor cells are positive for S-100 and numerous axons are present which stain for neurofilament protein.  The capsule is positive for EMA, in keeping with a perineurial origin.

Cases associated with this book:

Solitary circumscribed neuroma
Author: Stephen Lyle, M.D., Ph.D.

Conference: DermatopathologyConsultations.com Teaching Collection