Sean Klepper M.D.
Stephen Lyle, M.D., ...
- Most common on the face of middle-aged and older adults
- Presents as as a solitary skin-colored papule
- Well circumscribed intradermal nodule; rarely multinodular
- Partially encapsulated
- Composed of fascicles of spindle cells separated by artefactual clefts
- The cells have wavy, hyperchromatic nuclei and relatively abundant pale eosinophilic cytoplasm.
- Palisading is not typically a prominent feature, despite the alternative name of the tumor.
- The tumor may show attachment to a normal nerve.
- There is occasionally prominent vascularity.
- The tumor cells are positive for S-100 and numerous axons are present which stain for neurofilament protein. The capsule is positive for EMA, in keeping with a perineurial origin.