Sporotrichosis

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Caused by the fungus Sporothrix schenckii
    • "Rose gardener's disease": Sporothrix organisms found on plants are inoculated into the hand by penetrating trauma.
    • A hard nodule develops at the site of inoculation and the infection moves up the upper extremity by way of the lymphatics, with resulting regional lymphadenopathy.

    Histologic Features:

    • The diagnosis is best made by culture, since the organism is difficult to find histologically.
    • Early lesions show a nonspecific mixed inflammatory infiltrate.
    • Later lesions may show suppurative granulomas with concentric zones: central neutrophilic microabscesses surrounded by epithelioid macrophages, which are in turn surrounded by lymphocytes and plasma cells.
    • Asteroid bodies may be seen, and are characteristically extracellular, in contrast to the intracellular asteroid bodies seen in sarcoidosis and other granulomatous diseases.
    • If the organisms are visible on fungal stains, they appear as 3-8-micron round to cigar-shaped yeasts.
    External Links:

    Cases associated with this book:

  • Sporotrichosis
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection