Sweet's syndrome

    Clinical Features:

    • Disease of unknown etiology most commonly affecting adult women
    • Associated with hematopoietic malignancies, adenocarcinoma and upper respiratory tract infections
    • Patients present with tender violaceous nodules or plaques on the face, neck and upper extremities in conjunction with a flu-like illness.

    Histologic Features:

    • Dense, diffuse neutrophilic infiltrate involving the superficial and deep dermis
    • Prominent papillary dermal edema, sometimes causing subepidermal vesiculation
    • Intraepidermal spongiotic vesicles are sometimes seen.
    • Although not considered a vasculitic disorder, late-stage lesions may show secondary leukocytoclastic vasculitis.
    External Links:

    Cases associated with this book:

  • Sweet's syndrome
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection