Syringocystadenoma papilliferum

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Benign apocrine neoplasm which occurs on the head and neck in the vast majority of cases
    • Plaque or nodule with a verrucous surface, often with oozing
    • Sometimes associated with nevus sebaceus of Jadassohn
    • Sometimes congenital
    • Cured by simple excision

    Histologic Features:

    • Papillary projections into the lumen of a semicystic invagination in the epidermis
    • The epithelial lining of the invagination is in continuity with the epidermis.
    • The papillae are lined by a double layer of epithelium: an inner lining of cuboidal cells and an outer lining of apocrine-type cells with decapitation secretion.
    • The cores of the papillae are densely packed with plasma cells.
    • The base of the invagination displays tubular structures lined by tumor cells, which also grow superficially into the surrounding dermis.
    • Mucinous metaplasia may sometimes occur.
    • Mild cytologic atypia is sometimes present.
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