Sean Klepper M.D.
Artur Zembowicz M.D....
- Life-threatening blistering and desquamative disease, most often secondary to a drug reaction; AIDS is a risk factor.
- Diffuse erythema, often painful, progresses to blistering, ulceration and sloughing of skin with attendant risk of infection and fluid and electrolyte disturbances.
- High mortality rate
- Full-thickness, or nearly full-thickness necrosis of the epidermis (single cell necrosis may be seen at the periphery of the lesions)
- Separation of the epidermis from the dermis
- Little or no inflammation (some inflammation around the eccrine glands, however, is often seen)