Article Contributors: 
    Sean Klepper M.D.
    Stephen Lyle, M.D., ...

    Clinical Features:

    • Disease of unknown etiology (possibly autoimmune) characterized by slowly progressive patchy depigmentation of the skin secondary to loss of melanocytes
    • Most commonly begins on sun-exposed skin in a symmetrical distribution
    • There is a family history of the disease in many cases.
    • Associated with a plethora of other diseases, especially autoimmune diseases

    Histologic Features:

    • Complete absence of melanocytes and epidermal melanin
    • Biopsies from the periphery of lesions may show chronic inflammation in the papillary dermis.
    • Absence of melanocytes may be confirmed by MART-1 immunohistochemistry (S-100 also stains Langerhans cells, potentially yielding a false negative).
    • Absence of melanin may be confirmed by a Fontana-Masson stain.
    External Links:

    Cases associated with this book:

  • Vitiligo
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: Teaching Collection