Article Contributors:
Sean Klepper M.D.
Stephen Lyle, M.D., ...
Clinical Features:
- Acute-onset purpura, sometimes with eschars or blistering, most commonly on the trunk and lower extremities
- Associated with protein C deficiency
- Ranges from mild and self-limted to fulminant and fatal
Histologic Features:
- Epidermal necrosis with or without subepidermal blister formation
- Dermal necrosis, thrombi and red blood cell extravasation
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