Warfarin necrosis

    Article Contributors: 
    Sean Klepper M.D.
    Stephen Lyle, M.D., ...

    Clinical Features:


    • Acute-onset purpura, sometimes with eschars or blistering, most commonly on the trunk and lower extremities
    • Associated with protein C deficiency
    • Ranges from mild and self-limted to fulminant and fatal

    Histologic Features:

    • Epidermal necrosis with or without subepidermal blister formation
    • Dermal necrosis, thrombi and red blood cell extravasation
    External Links:

    Cases associated with this book:

  • Warfarin necrosis
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: DermatopathologyConsultations.com Teaching Collection