Also known as: mycormycosis, phycomycosis
- Infection caused by ubiquitous saprophytic fungi of several genera, including Mucor, Absidia, Rhizopus, Cunninghamella and Circinella
- Mainly affects immunocompromised hosts, in whom infection can be fatal
- Five clinical forms: rhinocerebral, pulmonary, gastrointestinal, cutaneous and disseminated
- There are two described variants of cutaneous zygomycosis:
- Subacute: Affects healthy hosts exposed to contaminated adhesive tape. Vesicles and pustules progressing to eschars.
- Rapidly progressive: Affects immunocompromised hosts. Necrotic black crust surrounded by cellulitis; may progress to disseminated disease.
- Extensive necrosis
- Vascular damage with fungal hyphae invading vessels (angioinvasion)
- The hyphae are visible on both H&E and special fungal stains. They are broad, normally nonseptate (although an occasional septum may sometimes be seen) and empty appearing ("ribbon like") with nonparallel walls and right-angle branching.