New England Journal of Medicine-Dermatology Articles
CORRESPONDENCE: Aprepitant for Erlotinib-Induced Pruritus
To the Editor: Aprepitant is the first commercially available drug of a new class of neurokinin-1âreceptor antagonists for treating chemotherapy-induced nausea and vomiting. The dominant ligand for the neurokinin-1 receptor...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Chloroquine-Induced Hair Hypopigmentation
A 16-year-old, blonde-haired patient was evaluated for a new band of lighter-colored hair located approximately 3 cm from the scalp. The patient first noted the change in hair color 1...
Categories: Dermatology
CLINICAL PROBLEM-SOLVING: A Rash Hypothesis
A 40-year-old woman presented with diarrhea, reporting to her physician that she had been having loose stools for 2 years, with 4 to 5 bowel movements per day, progressing over...
Categories: Dermatology
INTERACTIVE MEDICAL CASE: A Rash Hypothesis
A 40-year-old woman presented with diarrhea. It had begun 2 years ago with four to five loose bowel movements a day and progressed in recent months to 15 large-volume, watery...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Cutis Marmorata in Decompression Sickness
A 38-year-old man was transferred to the Diving and Hyperbaric Medicine Unit with decompression sickness 9 hours after a deep scuba dive to 54 m (177 ft). During the ascent,...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Piercing-Related Nontuberculous Mycobacterial Infection
An 18-year-old woman with the long-QT syndrome was referred to our dermatology clinic with a large, fluctuant, violaceous plaque on her right cheek (Panel A). Her right tragus had been...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Multiple Beau's Lines
A 69-year-old man was referred for the evaluation of changes to his fingernails that developed after the initiation of chemotherapy with docetaxelâcisplatinâfluorouracil for gastric cancer. Physical examination revealed multiple white...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Erythema Gyratum Repens
An 83-year-old man was evaluated for a 1-year history of a pruritic, progressively worsening migratory rash, with associated weakness and a 5-kg weight loss. He had a 30-pack-year history of...
Categories: Dermatology
ORIGINAL ARTICLE: Variant of and Autoimmunity Susceptibility Loci in Generalized Vitiligo
Background: Generalized vitiligo is an autoimmune disease characterized by melanocyte loss, which results in patchy depigmentation of skin and hair, and is associated with an elevated risk of other autoimmune...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Koilonychia
A 26-year-old malnourished woman presented with a 4-day history of mouth pain and a 3-month history of fatigue, general malaise, and palpitations. Physical examination revealed pallor of the conjunctiva and...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Nevoid Hyperkeratosis of the Nipple and Areola
A 28-year-old woman in her 5th month of pregnancy presented with a 2-month history of asymptomatic, irregular thickening of both nipples and the left areola. On physical examination, both nipples...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Hand, Foot, and Mouth Disease
A 4-year-old boy presented with a 5-day history of mild fever and malaise and a 3-day history of a vesicular rash involving his hands (Panel A), feet (Panel B), tongue...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Varicella Pneumonia in an Adult
A 26-year-old man presented with a 5-day history of cough, fever, and mild dyspnea. He had an exanthematous vesicular rash that had started 3 days before the respiratory symptoms began....
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Herpes Zoster
A previously healthy 57-year-old man presented to the emergency department with 4 days of worsening rash on the left side of his forehead (Panels A and B). He had been...
Categories: Dermatology
ORIGINAL ARTICLE: Corticosteroid Suppression of VEGF-A in Infantile Hemangioma-Derived Stem Cells
Background: Corticosteroids are commonly used to treat infantile hemangioma, but the mechanism of action of this therapy is unknown. We investigated the effect of corticosteroids in a previously described in...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Dermoscopy of Phthiriasis
A 50-year-old man presented with a 1-month history of mild, generalized pruritus. A total-body examination of the patient's skin revealed small, yellowish-brown flecks in the hair of the upper arm...
Categories: Dermatology
ORIGINAL ARTICLE: Oral Ivermectin versus Malathion Lotion for Difficult-to-Treat Head Lice
Background: Head-lice infestation is prevalent worldwide, especially in children 3 to 11 years old. Topical insecticides (i.e., pyrethroids and malathion) used as a lotion, applied twice at an interval of...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Neuropathic Ulceration
A 61-year-old man with a 15-year history of diabetes and resulting foot neuropathy presented with an ulcer of 3 months' duration overlying the first metatarsal head (Panel A). He was...
Categories: Dermatology
CLINICAL THERAPEUTICS: Permethrin and Ivermectin for Scabies
In a remote aboriginal community in tropical northern Australia, a mother comes to the health center with her 4-year-old son, who has multiple sores on the skin of his arms...
Categories: Dermatology
IMAGES IN CLINICAL MEDICINE: Cutaneous Leishmaniasis
A 25-year-old man presented to our clinic with a 1-year history of skin lesions on his nose and arm. Physical examination was notable for painless erythematous papules and nodules with...
Categories: Dermatology