2014 Guitart Pagetoid Reticulosis

    Multiple choice question

    Question prepared using materials provided by Dr. Joan Guitart, M.D


    Pagetoid reticulosis is a variant of Mycosis Fungoides. It is characterized by?

    2014 Jones MLL FISH

    Multiple choice question

    Question prepared using materials provided by Dr. Daniel M. Jones, M.D, Ph.D.


    The MLL gene, located at chromosome 11q23, is fused to many different translocation partners in acute lymphoid and myeloid leukemias. Cases with activated MLL usually have a poor prognosis. The assay showed below that can detect the most MLL translocations in acute leukemia is?

     

    2014 Jones IGH Gene Rearrangement Assay

    Multiple choice question

    Question prepared using materials provided by Dr. Daniel M. Jones, M.D, Ph.D.


    IGH PCR is generally a robust molecular assay. However, a significant limitation of the IGH B-cell gene rearrangement assay is?

    2014 Magro Pigmented Purpuric Dermatosis

    Multiple choice question

    Question prepared using materials provided by Dr. Cynthia Magro, M.D


    A patient presented with purpuric patches on the lower extremity. In reviewing his history, he remembers that they first developed 10 years ago and have been slowly progressing in size and number. A dermatologist performed a skin biopsy to rule out mycosis fungoides. The pathology is shown below.



     

    What is the most best diagnosis for this case?

    2014 Magro Indeterminate Cell Histiocytosis

    Multiple choice question

    Question prepared using materials provided by Dr. Cynthia Magro, M.D


    The indeterminate cell histiocytosis is a distinct form of Langerhans cell histiocytosis derived from the so called indeterminate cells. The lesions are typically multiple, may spontaneously regress, and in general follow a benign course. Phenotypic features of the indeterminate histiocytes include all of the following except?

    2014 Magro Cutaneous Intravascular Lymphomas

    Multiple choice question

    Question prepared using materials provided by Dr. Cynthia Magro, M.D


    Cutaneous intravascular lymphomas include intravascular B, NK, and anaplastic large cell lymphomas. Which of these lymphomas is the most common?

    2014 Karai 6p25.3 Translocation Associated Lymphomatoid Papulosis

    Multiple choice question

    Question prepared using materials provided by Dr. Laszlo Karai, M.D


    An 80-year-old female presents with multiple regressing nodular, erythematous lesions affecting the left leg. Lesional cells show positive results with CD4 and CD30 and negative for CD3, CD7, CD8, CD56, EMA, ALK-1. EBER in situ hybridization for Epstein-Bar virus is negative. Ki67 proliferation index is 80-90%. The 6p25.3 break apart probe is positive in tumor cells. The diagnosis is?

    2014 Chan Sweet’s Syndrome

    Multiple choice question

    Question prepared using materials provided by Dr. May Chan, M.D

    This lesion was taken from the leg of a patient with myelodysplastic syndrome. The sections show subcutaneous infiltrate with predominance of neutrophils consistent with subcutaneous Sweets syndrome.


    Which of the following findings would exclude a diagnosis of subcutaneous Sweet syndrome?

    2014 Kussick Cell Markers

    Multiple choice question

    Question prepared using materials provided by Dr. Steven J. Kussick, M.D

    Which of the following antigens is NOT highly specific for the indicated cell type or entity in the context of hematolymphoid cells?

    2014 Kussick Lymphoma Markers

    Multiple choice question

    Question prepared using materials provided by Dr. Steven J. Kussick, M.D

    Types of immunophenotypic aberrancy that are usually associated with lymphoid malignancy do NOT include which of the following?

    2014 Kussick Pseudolymphoma

    Multiple choice question

    Question prepared using materials provided by Dr. Steven J. Kussick, M.D

     

    Which of the following lymphoid growth patterns should NOT be identified in benign/reactive dermal lymphoid hyperplasia (“cutaneous pseudolymphoma”)?

    2014 Kussick Follicular Colonization

    Multiple choice question

    Question prepared using materials provided by Dr. Steven J. Kussick, M.D

    Which of the following terms describes the destructive infiltration of benign germinal centers by neoplastic B cells and/or plasma cells in marginal zone lymphoma?

    2014 Kempf Blastic Plasmacytoid Dendritic Cell Neoplasm 2

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D

    Which statement regarding blastic plasmacytoid dendritic cell neoplasm (BPDCN) is correct?

    2014 Kempf Blastic Plasmacytoid Dendritic Cell Neoplasm

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D

    The neoplastic cells in blastic plasmacytoid dendritic cell neoplasm (BPDCN), which is derived from plasmacytoid dendritic cells, display a specific phenotype. Which combination of markers is typically expressed by the tumor cells?

    2014 Kempf Primary Cutaneous Follicle Center Cell Lymphoma

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D


    Which statement about primary cutaneous follicle center cell lymphoma (PCFCL) is correct?

    2014 Kempf Primary Cutaneous Follicle Cell Lymphoma

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D


    Which statement on primary cutaneous follicle center lymphoma (PCFCL) is NOT correct?

    2014 Kempf Follicular Helper T-Cells

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D


    Which statement regarding follicular helper T-cells (FHT) is NOT correct?

    2014 Kempf Lymphomatoid Papulosis

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D


    Which statement regarding lymphomatoid papulosis is correct?

    2014 Kempf Anaplastic Large Cell Lymphoma

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D

    Which statement regarding primary cutaneous CD30+ anaplastic large cell lymphoma (ALCL) is NOT correct?

    2014 Zembowicz Rosai-Dorfman

    Multiple choice question

    Question prepared using materials provided by Dr. Artur Zembowicz, M.D, Ph.D.

    The biopsy below is from a 43 year old Asian-American female with a 4 month history of brownish dermal nodule on the chest. The biopsy shows the typical features of Rosai-Dorfman disease.

    Which of the following statements regarding this disease is correct?

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