2014 Kussick Lymphoma Markers

    Multiple choice question

    Question prepared using materials provided by Dr. Steven J. Kussick, M.D

    Types of immunophenotypic aberrancy that are usually associated with lymphoid malignancy do NOT include which of the following?

    2014 Kussick Pseudolymphoma

    Multiple choice question

    Question prepared using materials provided by Dr. Steven J. Kussick, M.D

     

    Which of the following lymphoid growth patterns should NOT be identified in benign/reactive dermal lymphoid hyperplasia (“cutaneous pseudolymphoma”)?

    2014 Kussick Follicular Colonization

    Multiple choice question

    Question prepared using materials provided by Dr. Steven J. Kussick, M.D

    Which of the following terms describes the destructive infiltration of benign germinal centers by neoplastic B cells and/or plasma cells in marginal zone lymphoma?

    2014 Kempf Blastic Plasmacytoid Dendritic Cell Neoplasm 2

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D

    Which statement regarding blastic plasmacytoid dendritic cell neoplasm (BPDCN) is correct?

    2014 Kempf Blastic Plasmacytoid Dendritic Cell Neoplasm

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D

    The neoplastic cells in blastic plasmacytoid dendritic cell neoplasm (BPDCN), which is derived from plasmacytoid dendritic cells, display a specific phenotype. Which combination of markers is typically expressed by the tumor cells?

    2014 Kempf Primary Cutaneous Follicle Center Cell Lymphoma

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D


    Which statement about primary cutaneous follicle center cell lymphoma (PCFCL) is correct?

    2014 Kempf Primary Cutaneous Follicle Cell Lymphoma

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D


    Which statement on primary cutaneous follicle center lymphoma (PCFCL) is NOT correct?

    2014 Kempf Follicular Helper T-Cells

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D


    Which statement regarding follicular helper T-cells (FHT) is NOT correct?

    2014 Kempf Lymphomatoid Papulosis

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D


    Which statement regarding lymphomatoid papulosis is correct?

    2014 Kempf Anaplastic Large Cell Lymphoma

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D

    Which statement regarding primary cutaneous CD30+ anaplastic large cell lymphoma (ALCL) is NOT correct?

    2014 Zembowicz Rosai-Dorfman

    Multiple choice question

    Question prepared using materials provided by Dr. Artur Zembowicz, M.D, Ph.D.

    The biopsy below is from a 43 year old Asian-American female with a 4 month history of brownish dermal nodule on the chest. The biopsy shows the typical features of Rosai-Dorfman disease.

    Which of the following statements regarding this disease is correct?

    2014 Zembowicz Necrobiotic Xanthogranuloma

    Multiple choice question

    Question prepared using materials provided by Dr. Artur Zembowicz, M.D, Ph.D.

    A 68 year old male with a past medical history of multiple myeloma associated with a paraproteinemia presents with multiple, crusted, red plaques on the scalp and torso. A biopsy was performed.


    What is the best diagnosis?

    2014 Zembowicz Primary Cutaneous Large B-cell Lymphoma, Leg Type

    Multiple choice question

    Question prepared using materials provided by Dr. Artur Zembowicz, M.D, Ph.D.

     

    The expected immunophenotype of primary cutaneous large B-cell lymphoma, leg type is?

    2014 Zembowicz Diffuse Large B-Cell Lymphoma

    Multiple choice question

    Question prepared using materials provided by Dr. Artur Zembowicz, M.D, Ph.D.

    The biopsy illustrated below is from an 84 year old female with a history of breast cancer presenting with a subcutaneous nodules on the left hip. Morphology of the lesion is consistent with diffuse large cell lymphoma. The lesion shows expression of CD20, MUM1, and Bcl2. It is negative for CD10 and Bcl6.

    Which statement regarding this case is NOT correct?

    2014 Zembowicz Sezary Syndrome

    Multiple choice question

    Question prepared using materials provided by Dr. Artur Zembowicz, M.D, Ph.D.

    The biopsy below is from a case of a patient presenting with erythroderma. The patient was treated for suspected eczema. As clinical response was limited a biopsy was performed to rule out Sezary Syndrome. The biopsy showed spongiotic dermatitis.



    Which of the following statements about this case is correct?

    2014 Zembowicz Follicular Mycosis Fungoides

    Multiple choice question

    Question prepared using materials provided by Dr. Artur Zembowicz, M.D, Ph.D.

    The slide below depicts subsets of mycosis fungoides recognized by the 2008 WHO subsets. D’emblee mycosis fungoides is no longer a recognized category and cutaneous T-cell lymphomas presenting de novo as plaques or tumors represent another category of T-cell lymphoma. Granulomatous mycosis fungoides is associated with a worse prognosis.

     

    What is the reason that follicular mycosis fungoides is separated?

    2014 Liu Indolent CD8-positive T Cell Lymphoid Proliferation

    Multiple choice question

    Question prepared using materials provided by Dr. Vincent Liu, M.D

    A 55 year old white male presents with a 1 cm skin-colored nodule on the right ear helix. It has been present for 2 years. The patient has a past medical history of diabetes mellitus and hypertension. A ROS is negative. A punch biopsy is done and shown below.



    What is the most likely diagnosis?

    2014 Liu Lymphoplasmacytic Plaque of Childhood

    Multiple choice question

    Question prepared using materials provided by Dr. Vincent Liu, M.D

    A 12 year old white female presents with an asymptomatic, erythematous 2cm plaque. It has been present on the left pretibial leg for one year. There has only been a slight improvement with application of a mid-potency topical steroid. A biopsy is done with a clinical impression of a spitz nevus vs. a hemangioma. It shows plasma cell-rich lymphocytic infiltrate. The punch biopsy is shown below.

    What is the most likely diagnosis?

    2014 Kempf Primary Cutaneous Follicle Center Lymphoma

    Multiple choice question

    Question prepared using materials provided by Dr. Werner Kempf, M.D


    A 57 year old male presents with a new growing nodule on the scalp. The lesion has been present for 4 months. The patient denies any other lesions, fevers, chills, night sweats, or a history of lymphoma. On exam is the lesion pictured below.


    Lymph node examination shows nothing palpable. A biopsy is done is the histology is shown next.


    Histology shows a superficial and deep nodular infiltrate with follicle formation.


    The follicles are composed mostly of centrocytes with some centroblasts. There is a lack of tingle body macrophages.


    Bcl-6 staining if positive in the follicles.


    Bcl-2 staining of the centroblasts is negative.

    What is the best diagnosis?

    2014 Guitart Primary Cutaneous Marginal Zone Lymphoma

    Multiple choice question

    Question prepared using materials provided by Dr. Joan Guitart, M.D


    Presented are classic features of marginal zone lymphoma found in the skin.


    Nodular pattern of infiltrate. Lighter and darker areas of zoning.


    Atrophic remnants of germinal centers.

    What feature would favor a primary cutaneous marginal zone lymphoma from a systemic marginal zone lymphoma with secondary metastasis to the skin?

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