Melanoma with epithelial differentiation and tumors with epithelial/melanocytic differentiation

    I have recently encountered a case of lentigo maligna melanoma associated with basaloid-looking dermal component. Immunohistochemical stains showed keratin and melanocytic marker expression in the dermal component.

    This case raised a critical differential diagnosis of a rare keratin-positive melanoma, collision tumor, a tumor with divergent melanocytic and epithelial differentiation. and melanoma colonizing basal cell carcinoma.

    Cases associated with this research project:

  • Basomelanocytic Tumour
    Author: Dr Richard A Carr MBChB; BMedSci; FRCPath; DipRCPath(DMT)

  • Another "baso/squamo-melanocytic tumor"
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • A controversial entity
    Author: DR Phillip H McKee MD, FRCPath

    Conference: Dr. Phillip H. McKee's teaching collection
  • Melanoma with areas of epithelial differentiation/malignant basomelanocytic tumor?, Case 1
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • Lahey Clinic Dermatology Grand Rounds 11/19/2008

    Event Date: 
    Wed, 11/19/2008 - 15:00 - 16:00

    Lahey Clinic Dermatology Ground Rounds will be held on Wednesday Nov 19, at 20 Wall Street, 2nd floor dermatology waiting room at 4:05 pm . If you have questions you can call Janet at 781-744-8444.

    Address: 
    ,

    Cases associated with this event:

  • 69 y/o female with longstanding h/o atopic dermatitis with severe flares
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • 67 years old woman with pigmented rash
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • 44 year old male with acute onset alopecia
    Author: Sarita Nori

    Conference: Dr. Z's Consultations
  • Case 49 (TB4)

    57 year old female with a purple-red plaque on the left side of the chest wall. PMH: Breast carcinoma treated with wide local excision and radiation.

    Online Only Case 3 (Brittle bones and a small subcutaneous mass)

    A 30-year-old patient presented with a pathologic hip fracture and osteomalcia.  A physical exam also discovered a small subcutaneous mass on the arm.

     

    Case 48 (TB8)

    60 year old female with a small papule on the left breast. PMH of breast carcinoma treted with wide local excision and radiation, 6 years previously.

    Case 30 (Something unexpected)

    A 31 year-old man presented with a nodular lesion on the arm.

     

     

    The case was discussed at the 2013 Dermpedia Comprehensive Course on Soft Tissue Tumors and Melanoma Update in Scottsdale, AZ

     

    Case 29 (I thought this was a bone tumor)

    27-year-old woman with a firm subcutaneous nodule on the forearm.

     

     

    The case was discussed at the 2013 Dermpedia Comprehensive Course on Soft Tissue Tumors and Melanoma Update in Scottsdale, AZ

     

    26 year old female with painful lesions on fingers and toes

    26 year old female referred for a complex 2 year history of painful red bumps on her fingertips and toes following an episode of abdominal pain 2 years ago. The patient reports that the lesions are very sensitive and painful to the touch and that they worsen with exposure to the cold. The patient has been worked up with numerous labs which have all been normal (SPEP neg, CBC, BMP, SSA, SSB, Rf, ANA, CRP, ESR, antiSCL070 Ab). She has been afebrile since her symptoms started. Of note, a biopsy done at an outside hospital showed interface dermatitis with necrotic keratinocytes.

    65 year old male with scaly pink papules on upper arms and trunk

    65 year old man with h/o Waldenstrom's Macroglobulinemia, on ibrutinib x 1 year and s/p chemo 1 year ago presents with rash on the trunk and upper extremities x 1-2 months. The patient reports that the rash is minimally itchy and slowly getting worse. Denies any bleeding of gums, Raynauds phenomena, or tiny firm bumps in his skin. The patient has a history of psoriasis treated topically. He reports no change in environment or medications prior to the onset of the new rash. No personal or family history of skin cancer.

    Buruli/Bairnsdale Ulcer

    57 year old man who works on a farm 50km from Melbourne, Australia ?SCC leg.  Previous cat scratch and leech bites in area.

    Conference: 

    8 month-old girl with acral and periorificial bullous lesions taken by the State into custody for suspected child abuse

    8 month-old girl with acral and periorificial bullous lesions taken by the State into custody for suspected child abuse. The biopsy was peroformed to rule out primary bullous disorder.

    Conference: 

    Drug-induced ulcers with hyalinizing vasculopathy

    81 year old F with 7-year history of polycythemia vera with recent onset of exquisitely-painful ulcers of her right calf

    Conference: 
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