Cellular blue nevi often show a mutation in which gene?
Images below are from a biopsy of "lentiginous melanoma"
Which statement regarding lentiginous melanoma is correct?
Which gene mutation is mostly associated with giant congenital nevus?
Which of the following signs is clinical diagnostic clue for subungual melanoma
A 28 year-old male presented with bulky mass on his ankle. The biopsy showed dermal tumor coposed of spindle and epithelioid cells with clear cytoplasm. Tumor cells were positive for S100 and HMB45. Which gene fusion do you have to reveal for proper diagnosis?
A 28 year-old male presented with bulky mass on his ankle. The biopsy showed dermal tumor composed of spindle and epithelioid cells with clear cytoplasm. Tumor cells were positive for S100 and HMB45. Identification of which gene fusion would confirm the diagnosis?
A 45 year-old female presented with vulva lesion. The biopsy showed junctional confluence of variable sized nests, and dermal nevoid cells. Nests were also spread along hair follicular epithelium. There was maturation with depth. There were large cells with prominent nucleoli in upper dermal nests, but there were no mitoses. What is your best diagnosis?
Which feature is most important for the diagnosis of acral melanoma rather than acral nevus?
Which dermoscopic feature is mostly suggestive of acral melanoma?
Which mutation subtype is mostly associated with lack of UV signature?