Which of the following secondary genomic alterations drives the metastatic potential of GNAQ-mutant malignant melanocytic neoplasms?
High tumor mutation burden may differentiate patients most likely to respond to which of the following melanoma therapies (pick all that apply)
Testing only for BRAF base substitutions is adequate for identifying patients who may respond to targeted therapy in which of the following:
The key role of the pathologist in the diagnosis of atypical (intermediate) melanocytic lesions is to:
Characteristics of melanomas in high CSD (chronic solar damage) skin include:
Staining for p16 in a Spitz nevus/tumor is appropriately used to:
A succinct histologic definition of a Spitz nevus/tumor is:
Which statement regarding so-called sclerosing atypical nevi (fibrosing dysplastic nevi) is correct?
Nevi are important mainly in relation to melanoma
In a recurrent melanocytic nevus
Criteria for diagnosis of melanoma are:
Syringotropic melanoma is defined as melanoma in situ spreading along eccrine ducts at depth greater than melanoma invading from the epidermis. Syringotropic melanoma can invade deep in the reticular dermis and subcutaneous tissue from within eccrine apparatus. Such syringocentric foci of invasion can be occult clinically.
Which statement regarding involving of eccrine ducts by melanocytic proliferations is not correct?
The sections show a biopsy of a conjunctival pigmented lesion. The lesion is associated with prominent conjunctival cysts.
Which statement regarding conjunctival cysts in melanocytic proliferations of the conjunctiva is correct?
Images below are from a biopsy of a slowly-growing (years) pigmented lesion in a young patient from a family with Carney complex. The best diagnosis in this case is?
Which statement about flourescence in situ hybridization in melanoma is not correct?
Which statement about malignant blue nevus/melanoma arising in blue nevus is not correct?
Intermediate melanocytic lesions are characterized by:
Evidence for the solar hypothesis of melanoma etiology includes:
Variants Nevoid melanoma (NvM), which is true?
Which statement about desmoplastic melanoma (DM) is true?