2017_Q38 Dermal nerve sheath myxoma

    Multiple choice question

    A female presented with an asymptomatic nodule on the finger. The biopsy showed:

    Nests of slightly atypical hyperchromatic spindle cells embeded in a myxoid stroma, with each nodule sharply demarcated from the other by thick fibrous bands. The spindle cells diffusely stained with S100 and GFAP. This tumor is best classified as a?

    2017_Q37 Malignant peripheral nerve sheath tumor

    Multiple choice question

    A biopsy was performed on a dermal nodule and showed the following histopathological findings: A poorly circumscribed proliferation of spindles cells primarily confined to the dermis. The proliferation was biphasic composed of hypercellular areas with fascicles and whorls of spindle cells adjacent to more hypocellular areas. The spindle cells stained focally with S100, Sox10, and CD34 and showed loss of staining with H3K27me3. Melanoma markers, epithelial membrane antigen, glial fibrillary acidic protein, neurofilament, pancytokeratin (AE1/AE3), CD34, smooth muscle actin, and desmin were negative.

    Based upon the histological finding and IHC profile this lesion is best characterized as a?

    2017_Q36 Spindle cell lipoma

    Multiple choice question

    The following biopsy was obtained from the finger of a 25-year-old women.

    The lesion was composed of mature fat, fasicles of CD34+ spindle cells with a school of fish  arrangement, ropey collagen, and myxoid stroma.

    Based upon clinical presentation, histological finding and IHC staning this lesion is best characterized as?

    2017_Q40 Multiple mitoses

    Multiple choice question

    Which feature is more common in melanoma, as compared to sclerotic nevi:

    2017_Q35 Ossifying fibromyxoid tumor

    Multiple choice question

    A 50-year-old male presented with an asymptomatic slowly growing nodule on his leg. A biopsy was performed and showed the following:

    Histological evaluation revealed a fairly well-circumscribed proliferation of epithelioid cells with indistinct cytoplasm arranged in nests and cords embedded in a fibromyxoid stroma surrounded by a fibrous pseudocapsule. Focally at the periphery there was mature bone. The tumor stained with S100, neurofilament, desmin, CD56, and INI1 staining showed a mosaic pattern with loss of expression in 50% of the cells.

    Based upon clinical presentation, histopathological findings and IHC profile the tumor is best classified as a:

    2017_Q34 Clear cell sarcoma

    Multiple choice question

    A 30-year-old male presented with a growing slightly painful deep seated lesion on his foot. A biopsy showed the following findings:

    In the dermis, there was a poorly circumscribed multilobulated proliferation composed of spindle cells arranged in fascicles admixed with epithelioid cells and floret-like multinucleated giant cells. Focally there were areas of necrosis and scattered mitoses. IHC was positive for S100, MITF, Melan-A, MITF. FISH break-apart probe detected EWS (22q12) gene rearrangement

    Based upon the above clinical and histopathological findings the tumor is best classified as?

     

     

    2017_Q33 Fibroepithelial stromal polyp

    Multiple choice question

    A 35-y/o female was found to have a polypoid lesion in her vagina that on biopsy showed:

    Based upon the clinical history and pathological findings this lesion is best classified as a?

    2017_Q41 True or False Pericytic tumors

    Multiple choice question

    True or False:

    Pericytic tumors (myofibroma and myopericytoma, glomus tumor and angioleimyoma) fall along a spectrum and morphologic overlap is often seen.

    2017_Q32 Well-differentiated liposarcoma

    Multiple choice question

    A 70-year-old male presented with an asymptomatic growing deep seated 7-cm mass on his right thigh. An incisional biopsy was performed and showed the following.

    Histological evaluation revealed a poorly circumscribed proliferation of mature fat that slightly varied in size which was separated by thicken fibrous septae. Focally some of the cells were larger and hyperchromatic, but no definitive lipoblasts were identified

    Based upon clinical presentation and histological findings this tumor is best classified as a?

    2017_Q31 Lipoblastoma

    Multiple choice question

    The following biopsy was from a growing deep seated mass on the back of an infant.

    The biopsy showed a poorly defined proliferation in the subcutis composed of fat of varying sizes and lipoblasts, separated by thick fibrous septae. Within the proliferation were a plexiform network of capillaries, and focal areas that were more myxoid.

    Based on the clinical presentation and histologic finding, this lesion is best classified as a?

    2017_Q30 Fibrous hamartoma of infancy

    Multiple choice question

    An 8-month-old presented with an axillary plaque that has been slowly growing x 2months. A biopsy was performed and showed the following findings:

    Within the deep dermis-subcutis there were interlacing torpedo-like fascicles of short spindle cells admixed with mature fate and small islands of immature round cells embedded in a myxoid stroma. The spindle cells were positive for SMA/desmin and negative for B-catenin, and primitive round cells were positive for CD34.

    Based upon clinical presentation, histopathological findings and immunohistochemical profile this lesion is best classified as a?

    2017_Q29 Dual expression of melanocytic and smooth muscle markers

    Multiple choice question

    What immunohistochemical profile is characteristic of and unique to a PEComa?

    2017_Q28 Cutaneous Rosai-Dorfman disease

    Multiple choice question

    A 55-year-old- women presented with a large hyperpigmented plaque on her buttock that was slightly pruritic. Other than well-controlled diabetes mellitus and hypertension, the patient had no evidence of lymphadenopathy, fever, night sweats, diabetes insipidus or osteolytic boney lesions. A biopsy was performed and showed the following features:

    Based upon clinical history, histopathology, and IHC profile the best diagnosis is?

    2017_Q27 Kaposiform Hemangioendothelioma

    Multiple choice question

    Which vascular abnormalities may be associated with platelet consumption or coagulation disorders?

    2017_Q26 Infantile Hemangioma

    Multiple choice question

    Which vascular lesion consistently shows expression of GLUT-1?

    2017_Q25 Myoepithelioma

    Multiple choice question

    A 50-year-old male presented with a subcutaneous slowly growing nodule on thigh that on biopsy showed the following findings:


    Histological evaluation revealed a well-circumscribed nodule composed of strands and nests of epithelioid-plasmacytoid cells with abundant cytoplasm embedded in a myxoid stroma. No ductal differentiation, significant atypia, or mitoses.

    Based upon clinical presentation, histopathological features and IHC profile this tumor is best classified as a:

    2017_Q28 Epithelioid hemangioendothelioma

    Multiple choice question

    What vascular tumor presents with cords of epithelioid cells embedded in a hyalinized stroma, admixed with vacuolated cells (blister cells) and stains with ERG and cytokeratin?

    2017_Q24 Endothelial marker

    Multiple choice question

    What is the most specific endothelial marker?

    2017_Q23 Glomeruloid hemangioma

    Multiple choice question

    An elderly woman with a long history of monoclonal gammopathy of undetermined significance (MGUS) presented with multiple scattered violaceous papules on her trunk. Her biopsy showed the following findings:

    Based upon clinical presentation and histopathological findings, what is the best diagnosis?

    2017_Q22 Spindle cell hemangioma

    Multiple choice question

    A 35-year-old female presented with a erythematous lesion on her palm. A biopsy was done and showed the following, IHC was negative for HHV8

    Based upon clinical presentation and histopathological findings, what is the best diagnosis?

    Syndicate content