Flourescence in situ hybridization (FISH) in diagnosis of melanocytic proliferations

    The objective of this project is to collect case illustrating practical applications of FISH test in diagnosis of malanoma and melanocytic proliferations.

    My intention is to post all my melanoma FISH cases which at this point count in hundreds.

    If you are new to melanoma FISH please download review "Update on Fluorescence in Situ Hybridization in Melanoma: State of the Art" by Gerami and Zembowicz

    I hope that you will find the ability to examine this cases useful in your practice and decisions regarding utility of FISH in your practice. 

    Please feel free to post your cases. Log-in is required to post a case.

    Dr. Artur Zembowicz

    Cases associated with this research project:

  • 41 year old female with likely melanoma on the thigh examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • Scottsdale 2012 Didactic Session I Lecture 4 Case 4
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • 30 year old male with atypical lesion on the calf examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 28 year old male with atypical melanocytic prolferation on the forearm examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 37 year old male with nevus with mitotic activity on the proximal forearm and negative FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 19 year old male with question of melanoma arising in a dermal nevus examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 37 year old female with question atypical nevus vs nevoid melanoma on the chest examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 31 year old female with atypical lesion on the upper leg examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 56 year old male with lesion on the back question spitzoid tumor vs. spitzoid melanoma examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 51 year old female with pigmented lesion on the cheek examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • Scottsdale 2012 Didactic Session I Lecture 4 Case 3
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • 80 year old male with an atypical pigmented lesion on the neck clinically suspicious for melanoma.
    Author: Artur Zembowicz M.D. Ph.D.

  • 26 year old female with atypical nevus on the thigh examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 31 year old female with dysplastic nevus on the abdomen examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 56 year old male with likely melanoma on the chest examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 14 year old male with atypical nevus on the scalp examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • Scottsdale 2012 Didactic Session I Lecture 4 Case 5
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • 33 year old female with an atypical lesion on the shoulder examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 51 year old female with pigmented lesion on the hand examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 25 year old female with atypical pigmented lesion on the ankle examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 33 year old female with atypical pigmented lesion on the forearm examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 54 year old male with likely blue nevus on the ear examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 38 year old male with atypical pigmented lesion on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 18 year old female with lesion on the calf of unknown duration examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 46 year old female with atypical pigmented lesion on the arm examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 34 year old female with lesion highly suspicious for melanoma on the upper arm examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 17 year old male with nevus on the upper inner thigh examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 24 year old female with atypical nevus on the scapula examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 60 year old male with atypical nevus on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 11 year old female with conjunctival nevus examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 28 year old female with thigh lesion examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 23 year old female with atypical vulvar nevus examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 16 year old female with lesion on the leg suspicious for spitzoid melanoma examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 44 year old female with d melanocytic proliferation on the hand examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 52 year old male with an atypical lesion to "rule out melanoma" on the abdomen examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 19 year old female with atypical lesion on the temple examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • Scottsdale 2012 Didactic Session I Lecture 4 Case 2
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • 4 year old male with atypical nevus on the leg examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 29 year old female with severe atypical nevus on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 24 year old female with atypical lesion on the calf, question Spitz nevus vs. Spitzoid melanoma, examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 21 year old female with atypical lesion on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 45 year old male with atypical nevus vs. nevoid melanoma on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 41 year old male with nevus on the posterior neck examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 38 year old male with lesion on the back suspicious for melanoma examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 32 year old female with severely atypical melanocytic proliferation on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 48 year old female with atypical nevus vs. nevoid melanoma on the nasal tip examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 42 year old female with dysplastic nevus vs melanoma on the scalp examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 52 year old male with ulcerated lesion on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 24 year old female with atypical genital nevus examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 53 year old female with severely atypical Spitz tumor vs spitzoid melanoma on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 64 year old male with atypical melanocytic proliferation on the elbow examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 53 year old male with likely melanoma on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 22 year old female with question melanoma on the upper arm examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 56 year old male with lesion on the back question spitzoid tumor vs. spitzoid melanoma examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 48 year old male with pigmented lesion on the upper arm examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 25 year old male with atypical nevus on the arm examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 40 year old male with atypical pigmented lesion on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 30 year old male with likely melanoma on the abdomen examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 56 year old male with atypical lesion on the back of unknown duration examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 25 year old female with likely Spitz tumor on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 43 year old female with atypical pigmented lesion on the calf/ankle of unknown duration examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 34 year old female with atypical pigmented lesion on the abdomen examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 75 year old male with likely melanoma on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 24 year old male with atypical nevus on the chest examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 16 year old male with pigmented lesion on the thorax examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 8 year old female with atypical nevus on the cheek examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 57 year old female with pigmented lesion on the back, question dysplastic nevus examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 3 year old male with atypical nevus on the ear of unknown duration examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 39 year old male with atypical papule on the chest examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 11 year-old girl with atypical nevus on the shoulder examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • Scottsdale 2012 Didactic Session I Lecture 4 Case 1
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • 48 year old male with lesion on the abdomen highly suspicious for melanoma examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 7 year old female with atypical nevus on the arm examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 29 year old female with nevus on the forearm examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 56 year old female with atypical nevus on the neck examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 40 year old female with likely dysplastic nevus on the shoulder examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 65 year old male with likely melanoma on the shoulder examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 67 year old male with atypical nevus on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 21 year old female with likely Spitzoid melanoma on the abdomen examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 28 year old male with atypical nevus on the forehead examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 47 year old female with atypical nevus on the chest aexamined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 31 year-old female with severely atypical pigmented lesion on the back examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 61 year old female with atypical nevus on the foot examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 61 year-old female with atypical pigmented lesion on the foot examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 56 year old male with atypical nevus on the ear lobe examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 28 year-old with atypical melanocytic vulvar lesion examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 36 year old female with lesion suspicious for melanoma examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 57 year old female with atypical erythematous lesion on the nose examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 9 year-old boy with conjunctival lesion examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 17 year-old girl with atypical lesion on the medial ankle examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 10 year-old boy with atypical lesion on the shoulder examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • A 32 year-old with atypical lesion on the shin, question Spitzoid tumor vs. spitzoid melanoma examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 33 year old male with lesion suspicious for melanoma on the lateral face examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 16 year old female with severely atypical melanocytic tumor on the anterior scalp examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 21 year old female with atypical lesion on the neck examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

  • 45 year old male with severely atypical melanocytic lesion examined by melanoma FISH.
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • 54 year-old male with a problematic combined melanocytic lesion and positive FISH
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • 45 year-old female with mitotically active compound melanocytic proliferation
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • Atypical compound Spitz tumor with negative FISH.
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • 10 year-old boy with clinically atypical changing pigmented mole: halo nevus with mitotic activity and negative FISH.
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • Small cell syringotropic melanoma, confirmed by FISH
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • Dermpedia Scottsdale 2011 Case: Suspected Pigmented Spindle Cell Nevus with Negative FISH
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • Dermpedia Scottsdale 2011 Course Case: Spitz nevus with negative FISH
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • Dermpedia Scottsdale 2011 Melanoma Course Case: Combined deep penetrating nevus with negative FISH
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • Dermpedia Scottsdale 2011 Course Case: Juvenile Conjunctival Nevus with False-Positive FISH
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations
  • Mitotically active atypical compound melanocytic proliferation with negative 4 probe MelanoSITE FISH
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dr. Z's Consultations