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Subcutaneous thrombotic vasculopathy/early calciphylaxis?

We have collected a series of 3 patients with painful ulcers and histological featuers characterized by thrombotic vasculopathy limited to the subcutaneous tissue capillaries.

The pattern of involvement of blood vessels is very similar to that in calciphylaxis, but calcifications have not been seen in routine sections or using Von-Kossa calcium stain.

More information about these cases will be presented shortly.

 

Cases associated with this research project:

  • 59 year-old diabetic woman with 6 month history of violaceous painful ulcerating nodules on inner thighs
    Author: Artur Zembowicz M.D. Ph.D.
    Diagnosis: Subcutaneous thrombotic vasculopathy, possible localized calciphylaxis
    clinical
    image    		clinical
    image    		he_1he_2he_3he_4

    Conference: Moschella/Miller and Zembowicz Weekly Dermatology/Dermatopathology Conference at Lahey Clinic
  • Subcutanous thrombotic vasculopathy
    Author: Artur Zembowicz M.D. Ph.D.
    Diagnosis: Subcutaneous thrombotic vasculopathy
    clinical
    image    		He1He2he3he4He5

    Conference: Moschella/Miller and Zembowicz Weekly Dermatology/Dermatopathology Conference at Lahey Clinic
  • Painful non-healing ulcerations
    Author: Dr. Danielle M Miller Ph.D., M.D., D.T.M.&H.
    Diagnosis: Subcutaneous thrombotic vasculopathy or early calciphylaxis?
    clinical
    image    		clinical
    image    		clinical
    image    		Subcutaneous thrombotic vasculopathySubcutaneous thrombotic vasculopathySubcutaneous thrombotic vasculopathy

    Conference: Moschella/Miller and Zembowicz Weekly Dermatology/Dermatopathology Conference at Lahey Clinic