38-year-old male, have fever and elevated transaminases for one month, have multiple tender subcutaneous nodules for 10 days.


36-year-old Chinese femal.
Asymtomatic thickened skin on palms and dosal hands for 2 years. No chemical contact history. Have depression history for several yeas, take 2 antidepressants( no details). Otherwise well. Negative family history.


Biopsy taken from dorsal knuckle. Picture above show seperated stratum corneum
A 15-year-old girl with congenital perceptive deafness, plantar keratodermia and numerous acneiform, cystic, pus-secreting nodules. A history of recidivant erythematous, gyrate changes (not evaluated by biopsy). This is a 1.5 cm nodule from the forehead with a small central opening.
Two prior biopsies in the archive - buccal erosions - nonspecific findings, vulvar erythematous papule - acanthotic, psoriasiform epidermis overlying abundant granulation tissue.
A connexin-26 (GJB-2) mutation - F142L type has been confirmed.
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