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Classic Example

88-year-old man with red-purple plaques on chest and face and a history of Waldenstrom's macroglobulinemia

Thu, 03/18/2010 - 17:42 — Artur Zembowicz M.D. Ph.D.
Contributor(s): 
Sean Klepper M.D.
Artur Zembowicz M.D. Ph.D.

88-year-old man with a one-year history of red to purple, asymptomatic, indurated plaques on his upper chest and back which the patient believes to be growing darker with time.  He also has a 8 year history of IgM monoclonal gammopath. The levels of macroglobulins were oscillating at the low levels consistent with Waldenstrom's macroglobulinemia. 

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7CD20 #1CD20 #2CD3 #1CD3 #2Kappa
Lambda
Diagnosis: 
Cutaneous extranodal marginal zone B-cell lymphoma with Waldenstrom's macroglobulinemia
Comment: 

The most common underlying cause of Wandenstrom's macroglobulinemia is lymphoplasmacytic lymphoma. Lymphoplasmacytic lymphoma typically involves bone marrow, spleen and lymph nodes. 

Cutaneous presentation of lymphoblastic lymphoma would be very rare. Also this patient has negative bone marrow.

Therefore, the case is best interpreted as extranodal marginal B cell lymphoma with monoclonal gammopathy.

Items this case is linked to:
Dermpedia textbook chapter: 
Primary cutaneous marginal zone B-cell lymphoma.
Conference: 
Dr. Z's Consultations

Erythema multiforme

Wed, 03/10/2010 - 20:32 — Artur Zembowicz M.D. Ph.D.
Contributor(s): 
Sean Klepper M.D.
Erythema multiforme 1Erythema multiforme 2Erythema multiforme 3Erythema multiforme 4Erythema multiforme 5
Diagnosis: 
Erythema multiforme
Items this case is linked to:
Dermpedia textbook chapter: 
Erythema multiforme
Conference: 
Dr. Z's Teaching Collection

Fixed drug eruption

Wed, 03/10/2010 - 20:22 — Stephen Lyle, M.D., Ph.D.
Contributor(s): 
Sean Klepper M.D.
Diagnosis: 
Fixed drug eruption
Items this case is linked to:
Dermpedia textbook chapter: 
Fixed drug eruption
Conference: 
Dr. Z's Teaching Collection

Fixed drug eruption

Wed, 03/10/2010 - 20:22 — Stephen Lyle, M.D., Ph.D.
Contributor(s): 
Sean Klepper M.D.
Fixed drug eruption 1Fixed drug eruption 2Fixed drug eruption 3Fixed drug eruption 4
Diagnosis: 
Fixed drug eruption
Items this case is linked to:
Dermpedia textbook chapter: 
Fixed drug eruption
Conference: 
Dr. Z's Teaching Collection

Lichenoid drug eruption

Wed, 03/10/2010 - 20:09 — Artur Zembowicz M.D. Ph.D.
Contributor(s): 
Sean Klepper M.D.
Lichenoid drug eruption 1Lichenoid drug eruption 2Lichenoid drug eruption 3Lichenoid drug eruption 4
Diagnosis: 
Lichenoid drug eruption
Items this case is linked to:
Dermpedia textbook chapter: 
Lichenoid drug eruption
Interface drug eruption
Conference: 
Dr. Z's Teaching Collection

Lichenoid keratosis

Wed, 03/10/2010 - 19:55 — Stephen Lyle, M.D., Ph.D.
Contributor(s): 
Sean Klepper M.D.
Lichenoid keratosis 1Lichenoid keratosis 2Lichenoid keratosis 3Lichenoid keratosis 4Lichenoid keratosis 5
Diagnosis: 
Lichenoid keratosis
Items this case is linked to:
Dermpedia textbook chapter: 
Lichenoid keratosis
Conference: 
Dr. Z's Teaching Collection

Lichen striatus

Wed, 03/10/2010 - 19:48 — Artur Zembowicz M.D. Ph.D.
Contributor(s): 
Sean Klepper M.D.
Lichen striatus 1Lichen striatus 2Lichen striatus 3Lichen striatus 4Lichen striatus 5
Diagnosis: 
Lichen striatus
Items this case is linked to:
Dermpedia textbook chapter: 
Lichen striatus
Conference: 
Dr. Z's Teaching Collection

Confluent and reticulated papillomatosis

Tue, 03/09/2010 - 21:23 — Stephen Lyle, M.D., Ph.D.
Contributor(s): 
Sean Klepper M.D.
Confluent and reticulated papillomatosis 1Confluent and reticulated papillomatosis 2Confluent and reticulated papillomatosis 3
Diagnosis: 
Confluent and reticulated papillomatosis
Items this case is linked to:
Dermpedia textbook chapter: 
Confluent & reticulated papillomatosis
Conference: 
Dr. Z's Teaching Collection

Secondary syphilis

Tue, 03/09/2010 - 21:03 — Stephen Lyle, M.D., Ph.D.
Contributor(s): 
Sean Klepper M.D.
Secondary syphilis 1Secondary syphilis 2Secondary syphilis 3Secondary syphilis 4Secondary syphilis 5Secondary syphilis 6
Diagnosis: 
Secondary syphilis
Items this case is linked to:
Dermpedia textbook chapter: 
Lichenoid (late) secondary syphilis
Psoriasiform secondary syphilis
Conference: 
Dr. Z's Teaching Collection

Pityriasis lichenoides et varioliformis acuta

Tue, 03/09/2010 - 20:51 — Artur Zembowicz M.D. Ph.D.
Contributor(s): 
Sean Klepper M.D.
Pityriasis lichenoides et varioliformis acuta 1Pityriasis lichenoides et varioliformis acuta 2Pityriasis lichenoides et varioliformis acuta 3Pityriasis lichenoides et varioliformis acuta 4
Diagnosis: 
Pityriasis lichenoides et varioliformis acuta
Items this case is linked to:
Dermpedia textbook chapter: 
Pityriasis lichenoides
Pityriasis lichenoides acuta
Conference: 
Dr. Z's Teaching Collection

Pityriasis lichenoides et varioliformis acuta

Tue, 03/09/2010 - 20:42 — Artur Zembowicz M.D. Ph.D.
Contributor(s): 
Sean Klepper M.D.
Pityriasis lichenoides et varioliformis acuta 1Pityriasis lichenoides et varioliformis acuta 2Pityriasis lichenoides et varioliformis acuta 3Pityriasis lichenoides et varioliformis acuta 4
Diagnosis: 
Pityriasis lichenoides et varioliformis acuta
Items this case is linked to:
Dermpedia textbook chapter: 
Pityriasis lichenoides
Pityriasis lichenoides acuta
Conference: 
Dr. Z's Teaching Collection

Erythema dyschromicum perstans

Sun, 03/07/2010 - 23:49 — Stephen Lyle, M.D., Ph.D.
Contributor(s): 
Sean Klepper M.D.
Erythema dyschromicum perstans 1Erythema dyschromicum perstans 2Erythema dyschromicum perstans 3
Diagnosis: 
Erythema dyschromicum perstans
Items this case is linked to:
Dermpedia textbook chapter: 
Erythema dyschromicum perstans
Conference: 
Dr. Z's Teaching Collection

Ulcerative lichen planus

Sun, 03/07/2010 - 23:37 — Artur Zembowicz M.D. Ph.D.
Contributor(s): 
Sean Klepper M.D.
Ulcerative lichen planus 1Ulcerative lichen planus 2Ulcerative lichen planus 3Ulcerative lichen planus 4Ulcerative lichen planus 5
Diagnosis: 
Ulcerative lichen planus
Items this case is linked to:
Dermpedia textbook chapter: 
Ulcerative (erosive) lichen planus
Conference: 
Dr. Z's Teaching Collection

Lichen planus hypertrophicus

Sun, 03/07/2010 - 23:16 — Stephen Lyle, M.D., Ph.D.
Contributor(s): 
Sean Klepper M.D.
Lichen planus hypertrophicus 1Lichen planus hypertrophicus 2Lichen planus hypertrophicus 3Lichen planus hypertrophicus 4
Diagnosis: 
Lichen planus hypertrophicus
Items this case is linked to:
Dermpedia textbook chapter: 
Lichen planus hypertrophicus
Conference: 
Dr. Z's Teaching Collection

Lichen planus atrophicus

Sun, 03/07/2010 - 22:59 — Artur Zembowicz M.D. Ph.D.
Contributor(s): 
Sean Klepper M.D.
Lichen planus atrophicus 1Lichen planus atrophicus 2Lichen planus atrophicus 3Lichen planus atrophicus 4
Diagnosis: 
Lichen planus atrophicus
Items this case is linked to:
Dermpedia textbook chapter: 
Lichen planus atrophicus
Conference: 
Dr. Z's Teaching Collection

Relapsing polychondritis

Fri, 03/05/2010 - 00:40 — Stephen Lyle, M.D., Ph.D.
Contributor(s): 
Sean Klepper M.D.
Relapsing polychondritis 1Relapsing polychondritis 2Relapsing polychondritis 3Relapsing polychondritis 4
Diagnosis: 
Relapsing polychondritis
Items this case is linked to:
Dermpedia textbook chapter: 
Relapsing polychondritis
Conference: 
Dr. Z's Teaching Collection

Supernumerary nipple

Fri, 03/05/2010 - 00:30 — Stephen Lyle, M.D., Ph.D.
Contributor(s): 
Sean Klepper M.D.
Supernumerary nipple 1Supernumerary nipple 2Supernumerary nipple 3
Diagnosis: 
Supernumerary nipple
Items this case is linked to:
Dermpedia textbook chapter: 
Supernumerary nipple
Conference: 
Dr. Z's Teaching Collection

Accessory tragus

Fri, 03/05/2010 - 00:22 — Artur Zembowicz M.D. Ph.D.
Contributor(s): 
Sean Klepper M.D.
Accessory tragus 1Accessory tragus 2Accessory tragus 3
Diagnosis: 
Accessory tragus
Items this case is linked to:
Dermpedia textbook chapter: 
Accessory tragus
Conference: 
Dr. Z's Teaching Collection

Subcutaneous fat necrosis of the newborn

Fri, 03/05/2010 - 00:12 — Artur Zembowicz M.D. Ph.D.
Contributor(s): 
Sean Klepper M.D.
Subcutaneous fat necrosis of the newborn 1Subcutaneous fat necrosis of the newborn 2Subcutaneous fat necrosis of the newborn 3Subcutaneous fat necrosis of the newborn 4
Diagnosis: 
Subcutaneous fat necrosis of the newborn
Items this case is linked to:
Dermpedia textbook chapter: 
Subcutaneous fat necrosis of the newborn
Conference: 
Dr. Z's Teaching Collection

Membranous lipodystrophy

Thu, 03/04/2010 - 23:53 — Artur Zembowicz M.D. Ph.D.
Contributor(s): 
Sean Klepper M.D.
Membranous lipodystrophy 1Membranous lipodystrophy 2Membranous lipodystrophy 3Membranous lipodystrophy 4Membranous lipodystrophy 5Membranous lipodystrophy 6
Membranous lipodystrophy 7
Diagnosis: 
Membranous lipodystrophy
Items this case is linked to:
Dermpedia textbook chapter: 
Membranous lipodystrophy
Conference: 
Dr. Z's Teaching Collection
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