Large plaque parapsoriasis

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Also known as: parapsoriasis en grandes plaques

    Clinical Features:

    • Controversial relationship with mycosis fungoides: some consider it an inflammatory process that may progress to MF, whereas others believe it to be part of the spectrum of presentations of MF
    • Large (>10 cm), scaly, erythematous patches and plaques, most commonly on the buttocks, flexural surfaces and breasts
    • A chronic disease most often affecting middle-aged individuals
    • May progress to mycosis fungoides, with thickening of the plaques

    Histologic Features:

    • Early lesions show only a superficial perivascular lymphocytic infiltrate.
    • As the lesion progresses, the epidermis develops mild irregular acanthosis with mounds of parakeratosis.
    • In chronic lesions, there is a dense bandlike lymphocytic infiltrate, dermal fibrosis, basal vacuolar change and pigment incontinence.
    • In all stages, the lymphocytic infiltrate is composed of monoclonal T-cells.

    External Links:

    Cases associated with this book:

  • Large plaque parapsoriasis
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Teaching Collection