Pretibial myxedema

    Clinical Features:

    • Seen in patients with treated hyperthyroidism
    • Elevated knobby plaques or nodules with a waxy surface on the shins and occasionally dorsal feet 


    Histologic Features:

    • Expansion of the dermis, most prominently the deeper dermis, by abundant mucin separating the collagen bundles (strongly Alcian blue positive)
    • Fibroblasts appear to float in edematous areas.
    • Lymphatic dilatation may be present.
    • Fibrosis of the deep dermis and subcutis in older lesions


    External Links:

    Cases associated with this book:

  • Pretibial myxedema
    Author: Stephen Lyle, M.D., Ph.D.

    Conference: Teaching Collection