Toxic epidermal necrolysis

    Article Contributors: 
    Sean Klepper M.D.
    Artur Zembowicz M.D....

    Clinical Features:

    • Life-threatening blistering and desquamative disease, most often secondary to a drug reaction; AIDS is a risk factor.
    • Diffuse erythema, often painful, progresses to blistering, ulceration and sloughing of skin with attendant risk of infection and fluid and electrolyte disturbances.
    • High mortality rate

    Histologic Features:

    • Full-thickness, or nearly full-thickness necrosis of the epidermis (single cell necrosis may be seen at the periphery of the lesions)
    • Separation of the epidermis from the dermis
    • Little or no inflammation (some inflammation around the eccrine glands, however, is often seen)
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    Cases associated with this book:

  • Toxic epidermal necrolysis
    Author: Artur Zembowicz M.D. Ph.D.

    Conference: Dermpedia Teaching Collection